Aspirin is the prototypical analgesic used in the treatment of mild to moderate pain it has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin has been used as a medicine by the ancient greeks and the pharaohs of egypt it is effective in reducing pain (it is an analgesic), reducing inflammation (anti-inflammatory), reducing fever (antipyretic), and thinning blood (anti-coagulant. Introduction in this experiment you will be synthesizing an organic compound, acetylsalicylic acid (known as aspirin) using an organic reaction. The chemical equation for the synthesis of aspirin is c7h6o3 + c4h6o3 - c9h8o4 +c2h4o2, which is a reaction of salicylic acid with acetic anhydride in the presence of phosphoric acid. Chemistry- aspirin lab question in lab today, we measured the actual yield and melting point of aspirin that we had made in lab last week if your synthesis was.
Synthesis of aspirin introduction aspirin is one of the milder and least expensive pain relievers available today, americans spend about $2 billion a year for non. Purpose the purpose of this lab was to synthesize aspirin and measure the synthesized aspirin's purity by calculating the theoretical yield based on the original amount of salicylic acid, one could determine the actual yield percentage of the reaction. Safety the chemicals used to synthesize aspirin present a health hazard and exposure should be kept to a minimum: 1) sulfuric acid: a highly corrosive liquid that will cause severe burns if it comes into contact with. Aspirin is salicylic ester of acetic acid and can be prepared by reaction of salicylic acid with acetic acid catalyzed by acid however this reaction is reversible one and after attaining equilibrium may reverse leading to hydrolysis of ester as shown in figure below thus required amount of aspirin.
Synthesis of aspirin aspirin or acetyl salicylic acid (asa) is a derivative of salicylic acid, which is used as a pain reliever for various body ailments such as head ache aspirin shows anti-platelet or anti- coagulant properties by inhibiting the prostaglandins, thereby repairing damaged blood vessels.  a dose of 40 mg of aspirin a day is able to inhibit a large proportion of maximum thromboxane a 2 release provoked acutely, with the prostaglandin i2 synthesis being little affected however, higher doses of aspirin are required to attain further inhibition. The goal of this lab is to synthesize aspirin using acid & base catalysis aspirin is an analgesic anti-inflammatory drug it is one of the oldest and widely used drugs in medicine. Aspirin became commercially available in 1899 and today it is estimated that over a trillion aspirin tablets have been consumed by those in need of its curative effects in this experiment aspirin was synthesized from salicylic acid and acetic anhydride.
Considerations when seeking synthesis of aspirin lab report writing help it is increasingly becoming apparent to students and instructors that the quality of scientific writing is just as significant as experimenting or investigating. Synthesis of aspirin introduction: aspirin, or acetylsalicylic acid, is one of the most widely produced drugs in the world in the us alone, over 25 billion tablets are made. Exercise 11 synthesis of aspirin (acetylsalicylic acid from salicylic acid) sharmaine s bungabong group 2 5l i introduction organic synthesis is an important aspect in the industry of organic chemistry this aspect of organic chemistry has contributed much to the knowledge there is regarding the. The wide range of effects that aspirin can produce made it difficult to pinpoint how it actually works, and it wasn't until the 1970s that biologists hypothesized that aspirin and related drugs (such as ibuprofen) work by inhibiting the synthesis of certain hormones that cause pain and inflammation.
Aspirin synthesis tap water was heated on a steam bath in a 250 ml beaker the temperature of an alcohol thermometer was equilibrated in a beaker of room temperature tap water the temperature of an alcohol thermometer was equilibrated in a beaker of room temperature tap water. A continuation of the aspirin synthesis lab in this lab, you will determine the percent purity of your product from the aspirin synthesis using an acid- base titration. Anal 2a1 synthesis of aspirin experimental techniques required recrystallisation (t 2), filtration (t 3), melting point determination (t 4), yield calculation (t 14.
Synthesis and analysis of aspirin lab adv comp 22 from advanced chemistry with vernier, vernier software & technology, 2004 introduction aspirin, the ubiquitous pain reliever, goes by the chemical name acetylsalicylic acid. Abstract: the synthesis of aspirin is a part of many undergraduate organic synthesis labs and is frequently used in qualitative organic analysis laboratory for the identification of salicylic acid we have found that aspirin can be synthesized on microscale by a. 4 a buffer will stabilize the ph to a desired level purpose: to synthesize and purify aspirin from salicylic acid and acetic anhydride procedure: day 1: 1 weigh and put 10g salicylic acid into 50ml erlenmeyer flask. Synthesis of aspirin (acetylsalicylic acid) place 20 g (0015 mole) of salicylic acid in a 125-ml erlenmeyer flask add 5 ml (005 mole) of acetic anhydride, followed by 5 drops of conc h 2 so 4 (use a dropper, h 2 so 4 is highly corrosive) and swirl the flask gently until the salicylic acid dissolves.
82 experiment 5: synthesis of aspirin • report data collected and subsequent calculations to wwwchem21labscom • all equipment should be returned to the correct location after use. Aspirin is the only over-the-counter analgesic approved for prevention of cardiovascular disease new research suggests that aspirin may also decrease the risk of some forms of stroke additional studies indicate that aspirin may play a role in reducing the risks of ovarian cancer. Because acetyl salicylic acid, aka aspirin, has an acetate group, and acetic anhydride has one that is a good leaving group the typical lab-ready reaction for this synthesis is: basically, the acid acts as a catalyst (not protonating water though, because acetic anhydride is violently reactive with water), and the hydroxyl on 2-hydroxybenzoic acid acts as a nucleophile. Preparation, purification and analysis of aspirin (acetylsalicylic acid) synthesis: we will prepare aspirin by reacting salicylic acid 1 with an excess of acetic anhydride 2.
If aspirin forms in the filtrate in the vacuum flask, transfer the filtrate and aspirin to a beaker, chill in an ice bath, and vacuum filter as before, using a new piece of filter paper dispose of the filtrate in the sink. Preparation of aspirin 1 purpose: the purpose of this experiment is to prepare acetylsalicylic acid, aka aspirin introduction: an important part of chemistry is the preparation, or synthesis, of compounds from simpler start.